Effects of ovarian stimulation protocols on outcomes of assisted reproductive technology in adenomyosis women: a retrospective cohort study

Objective To evaluate the effects of different ovarian stimulation protocols on in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) outcomes infertile women with adenomyosis. Methods We carried out a retrospective cohort study among adenomyosis receiving IVF/ICSI treatment, including 257 fresh embryo transfer (ET) cycles and 305 frozen (FET) cycles. In ET cycles, ultra-long, long, short, antagonist were adopted. FET patients received long-acting GnRH agonist (GnRHa) pretreatment or not. The primary outcome was clinical pregnancy rate (CPR), secondary included implantation (IR), miscarriage (MR), live birth (LBR). Results compared ultra-long long protocols, IR (49.7%, 52.1% versus 28.2%, P=0.001) CPR (64.3%, 57.4% 35.6%, P=0.004) significantly decreased short protocol. Similarly, inclination 33.3%) (57.4%, 64.3% 38.2%) existed protocol, although no statistical significance detected because strict P adjustment Bonferroni method (P adj =0.008). Compared LBR protocol obviously (48.2% 20.3%, P<0.001). matter which origin embryos, there differences IR, CPR, LBR. For ≥35 years ET, higher (52.1%, 50.0% 20.0%, 27.5%, P=0.031) to protocols. FET, embryos originating from had proportions GnRHa (30.4%,30.00 63.9%, 51.4%, P=0.009). (61.1%, 48.6% 32.6%, 25.0%, P=0.020) (58.3%, 30.4%, P=0.024) than rates but supported Conclusion adenomyosis, if planned for transfer, an might be beneficial. If used, whole followed by recommended. derived impact outcomes.